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According to Charles Estienne and Jean Liebault, Nicot then sent a sample of the tobacco plant with a description of its uses "to a certeine Phistion of the king of Pourtugall [possibly Fernando Mendez] one of the greatest to examine the further working and effect of the said Nicotaine " who, upon examining the patient agreed with Nicot's estimation of the plant

EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as tobacco cigarettes substitute: a prospective 12-month randomized control design study

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R., Modell, J